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与胎儿宏观症相关的环境风险因素:一个总体审查

Ensiyeh Jenabi¹, Amir Mohammad Salehi², Sajjad Farashi³

¹Mother and Child Care Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.

Pediatrics and neonatology

|January 9, 2024

概括

晚年母亲的年龄,妊娠前的肥胖和过度体重增加是胎儿宏观症的关键环境风险因素. 孕期糖尿病也为此做出了贡献,突出了怀孕前健康管理的必要性.

科学领域:

生殖健康生殖健康
环境医学环境医学
围产期流行病学围产期流行病学

背景情况:

胎儿宏观症,定义为出生体重过重,与新生儿和母亲的不良结果有关.
在设计前确定环境风险因素对于有针对性的干预至关重要.
现有的审查往往侧重于单一因素或特定人群,需要全面的概述.

研究的目的:

进行对元分析和系统审查的综合审查,评估胎儿宏观症的孕前环境风险因素.
综合关于母亲特征和生活方式因素与胎儿宏观症之间的关联的证据.
对已识别的风险因素的证据强度进行分级.

主要方法:

在PubMed,Scopus和Web of Science数据库中进行系统搜索,直到2023年4月.
包括元分析和系统审查,评估胎儿宏观症的环境风险因素.
使用AMSTAR 2检查清单进行包含研究的质量评估.

主要成果:

提示性证据 (III类) 确定了先进的母亲年龄 (35-39岁),孕前肥胖和过度体重增加 (怀孕前和怀孕期间).
较弱的证据 (第四类) 确定了晚期母亲年龄 (>40岁) 和妊娠期糖尿病 (GDM) 没有使用胰岛素.
确定的主要环境风险因素包括先进的母亲年龄,妊娠前肥胖,过度体重增加和不使用胰岛素的GDM.

结论:

晚年母亲的年龄,妊娠前的肥胖,过度体重增加和GDM是胎儿宏观症的重要环境风险因素.
这些发现强调了怀孕前咨询和母亲健康状况管理的重要性.
进一步的研究可能是有必要的,以探索机制,并完善干预措施,以防止巨.

关键词:

麦克罗索米亚 (Macrosomia) 是一个宏观的现象.进行元分析分析.风险因素风险因素雨研究是一项总体研究.

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