CD70在原发性和转移性清细胞细胞癌中一致表达
Rong Rong Huang1, Zhengshan Chen2, Nils Kroeger3
1Department of Pathology and Laboratory Medicine, University of California Los Angeles, David Geffen School of Medicine, Los Angeles, CA.
Clinical genitourinary cancer
|January 9, 2024
概括
CD70在清细胞细胞癌中经常过度表达,支持其作为治疗点的作用. 主要瘤组织与转移性瘤具有很高的一致性,这表明它在未来的临床试验中很有用.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 分子生物学分子生物学
背景情况:
- CD70在细胞癌 (RCC) 中过度表达,是潜在的治疗点.
- 转移性RCC中CD70表达频率尚未得到充分确立.
研究的目的:
- 评估CD70在原发性和转移性瘤中的表达频率和模式.
- 评估CD70作为透明细胞RCC的潜在治疗点.
主要方法:
- 免疫组织化学用于评估391个初级RCC和72个转移性RCC的CD70表达.
- 分析包括26名患者的对联原发性和转移性瘤.
主要成果:
- CD70在清晰细胞RCC中经常过度表达,但在 papillary RCC中很少出现.
- 在透明细胞RCC中,CD70表达与缺氧通路蛋白相关.
- 在配对的原发性和转移性瘤之间观察到高一致率 (85%).
结论:
- CD70是转移性清晰细胞RCC的一个有前途的治疗点.
- 在未来的试验中,原发性瘤组织可以作为转移性组织的替代体.
关键词:
CD7070 CD7070 CD7070 CD7070 CD70 CD70 CD70 CD70 CD70 CD70 CD70 CD70 CD70 CD70 CD70 CD70 CD70 CD70 CD70 CD70 CD70 CD70 CD70 CD70 CD70 CD70 CD70 CD70 CD70 CD70 CD70 CD70 CD70 CD70 CD70 CD70 CD70 CD70 CD70 CD70 CD70 CD70 CD70 CD70 CD70 CD70 CD70 CD70 CD70 CD70 CD70 CD70 CD70 CD70 CD70清除细胞清除细胞氧气过低是因为缺氧.细胞癌是细胞癌.有针对性的治疗.更多相关视频
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