从载体混合物中制备和评估喷雾干燥的可吸入微粒
概括
这项研究探讨了用于干粉肺药物输送的微粒配方. 马尔托德克斯和孔德罗伊微粒显示出有希望的气溶性质和用于肺部治疗的可加工性.
科学领域:
- 制药科学 制药科学
- 药物输送系统 药物输送系统
- 生物材料是一种生物材料.
背景情况:
- 微粒子配方是有效的干粉肺药物输送的关键.
- 载体特性显著影响微粒子特性和气溶化.
- 碳水化合物载体与凝剂相结合,具有可控的药物释放潜力.
研究的目的:
- 用糖基载体和凝聚合物制备和评估微粒.
- 为了确定最佳的载体组合用于肺部药物输送.
- 评估微粒物质的特性,以便在随后的药物内置中使用.
主要方法:
- 用于制备十批微粒的喷雾干燥技术.
- 评估微粒物质的特性,包括空气动力学直径和细粒物质的分数.
- 对载体组合的评估:曼尼托尔,马尔托德克斯特林,用奇托桑添加的德克斯,德罗硫酸盐.
主要成果:
- 确定了气动直径接近5微米和高微粒分数 (>43%) 的批量.
- 最佳的载体组合包括曼尼托尔/德克斯,奇托桑/冠状素和马尔托德克斯/冠状素.
- 马尔托德克斯和冠状素的组合显示出由于粘度较低和粒子形状规律的优越可加工性.
结论:
- 基于糖的载体和凝聚合物的组合适用于肺部药物输送.
- 特定的配方,特别是马尔托德克斯和冠状素,显示出吸入疗法的潜力.
- 进一步的研究可以专注于将药物纳入这些优化的微粒子矩阵.
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