两种乳杆菌菌株作为辅助疗法治疗易怒肠综合征:一个随机对照试验
概括
添加益生菌,特别是Lactobacillus acidophilus和Lactobacillus plantarum,显著改善了腹占主导地位的刺激性肠综合征 (IBS-D) 患者的症状. 与单独标准治疗相比,这种益生菌干预导致更大的症状缓解和缓解率.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 临床营养学 临床营养学
背景情况:
- 刺激性肠综合征 (IBS) 是一种常见的胃肠疾病,对生活质量产生重大影响.
- 腹占主导地位的IBS (IBS-D) 在症状管理方面提出了独特的挑战.
- 益生菌越来越多地被探索为IBS的治疗选择.
研究的目的:
- 在IBS-D患者中评估含有Lactobacillus acidophilus和Lactobacillus plantarum的多菌株益生菌的疗效.
- 为了比较益生菌补充剂加标准治疗与单独标准治疗对IBS症状严重性的影响.
主要方法:
- 一个随机的,单盲临床试验,涉及100名IBS-D患者.
- 患者被分配接受标准IBS治疗或标准治疗加上多菌株益生菌12周.
- 在干预期之前和之后,使用IBS - 症状严重程度量表 (IBS-SSS) 评估症状严重程度.
主要成果:
- 与标准治疗组 (A组,241分) 相比,益生菌组 (B组) 的整体IBS-SSS得分显著减少 (307分).
- 在益生菌组的疼痛频率,腹部张张的严重程度,肠道症状的满意度和IBS对生活的影响方面观察到显著的改善.
- 在治疗后,益生菌组的100%患者实现了完全缓解或轻度症状,而标准治疗组的85.7%.
结论:
- 含有L. acidophilus和L. plantarum的多菌株益生菌在加入标准治疗时有效缓解腹占主导地位的IBS症状.
- 益生菌补充剂在改善IBS-D患者的整体IBS症状严重程度和生活质量方面具有显著的益处.
- 这些发现支持将益生菌纳入用于管理IBS-D的临床指南.
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