边际状况对高风险群体中类型瘤复发的影响:一项追溯观察性研究
Aliyeh Ranjbar1, Vahid Zangouri2,3, Mansoureh Shokripour4
1Breast Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
BMC cancer
|January 9, 2024
概括
菲洛德瘤 (PT) 影响复发的外科手术边缘. 虽然负边缘对于良性或边缘PT并不总是必要的,但它们可以减少较大的瘤或带有瘤过度生长的瘤的复发. 密切的跟进是关键.
科学领域:
- 在瘤学瘤学.
- 手术病理学手术病理学
- 乳房手术 乳房手术
背景情况:
- 囊瘤 (PT) 是纤维皮质乳腺瘤,具有很大的局部复发风险.
- 对于PT切除的最佳外科边缘仍然是争论的主题,特别是在具有正边缘的病例中.
- 确定复发风险因素和外科手术边缘的影响对于有效的PT管理至关重要.
研究的目的:
- 为了确定与phyllodes瘤复发相关的风险因素.
- 评估自由手术边缘对瘤复发的影响,考虑已识别的风险因素.
- 为了告知外科手术决策和后续策略的phyllodes瘤.
主要方法:
- 对319名经过手术治疗的PT患者进行了回顾性观察性研究.
- 从2001年至2020年期间从医疗记录中收集的数据.
- 至少3年的随访时间,以评估局部复发和远程转移.
主要成果:
- 良性,边缘性和恶性PT分别占病例的83.9%,7.6%和8.5%.
- 总体而言,局部复发率为8.8%,非恶性病例为7.6%.
- 复发风险因素包括口服避孕药的使用,吸烟,瘤大小>4厘米,树突过度生长和树突细胞缺陷. 负边际显著降低了>4厘米的瘤和瘤过度生长的复发.
结论:
- 负边际并没有持续降低良性和边界类瘤的复发率.
- 密切的患者随访是对非恶性PT的强制性负边际的合理替代方案.
- 负边际可能有助于减少特定高风险PT群体的复发,例如较大的瘤或带有瘤过度生长的瘤.
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