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长期COVID中消化系统疾病的风险:基于人口的队列研究的证据
Yuying Ma1,2, Lijun Zhang1,3, Rui Wei1
1Department of Gastroenterology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.
COVID-19幸存者面临各种消化系统疾病的长期风险增加,包括GERD和GI功能障碍. 这些风险随着COVID-19的严重程度和再感染而升级,甚至在一年后仍然存在.
科学领域:
- 胃肠病学 胃肠病学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 人们越来越担心COVID-19在后疫情时代的后果.
- 在COVID-19感染后对长期消化系统疾病风险的理解有限.
- 需要对长期COVID患者的胃肠道并发症进行全面评估.
研究的目的:
- 研究COVID-19患者中患上消化系统疾病的长期风险.
- 量化COVID-19感染与各种胃肠道结果之间的关联.
- 探索COVID-19的严重程度和再感染如何影响消化疾病风险.
主要方法:
- 使用英国生物库数据的大规模回顾性队列研究 (长达2.6年的随访).
- 将COVID-19患者 (n=112,311) 与当代 (n=359,671) 和历史 (n=370,979) 控制组进行比较.
- 使用反向概率权重的考克斯回归模型来计算感染后≥30天诊断的消化结果的危险比率 (HR).
主要成果:
- 与对照组相比,COVID-19患者的胃肠道 (GI) 功能障碍,胃潰瘍疾病,GERD,胆囊疾病,严重肝病,非酒精性肝病和胰腺疾病风险较高.
- GERD和胃肠道功能障碍的风险持续超过感染后的一年.
- COVID-19的严重程度与GERD风险增加相关,再感染显著增加了胰腺疾病的风险.
结论:
- COVID-19与各种消化系统疾病的长期风险显著增加有关.
- 消化系统疾病的风险随着COVID-19的严重程度和再感染而升级,随着时间的推移而持续.
- 这些发现强调了针对COVID-19患者的量身定制后续策略的必要性,特别是那些严重感染或再感染的患者.
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