针对细胞癌的细胞疗法的发展
Yufei Wang1,2, Eloah Rabello Suarez3,4, Gabriella Kastrunes1
1Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA.
Molecular cancer
|January 9, 2024
概括
细胞疗法为治疗晚期细胞癌 (RCC) 提供了新的希望. 本综述探讨了各种细胞疗法,包括CAR T细胞和树突细胞疫苗接种,以寻找潜在的RCC治疗方法.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 细胞疗法细胞疗法
背景情况:
- 细胞癌 (RCC) 治疗已经显著发展,但治疗晚期瘤仍然具有挑战性.
- 虽然细胞疗法已经治愈了血液性恶性瘤,但其转化到像RCC这样的固体瘤是一个活跃的研究领域.
研究的目的:
- 为细胞癌 (RCC) 提供当前和新兴细胞疗法的全面概述.
- 突出基于细胞的治疗方法在RCC患者中实现治愈结果的潜力.
主要方法:
- 对RCC应用的各种细胞疗法的现有文献的审查.
- 专注于全源造血干细胞移植,T细胞受体基因修饰的T细胞,仿真抗原受体 (CAR) T细胞,CAR自然杀手 (NK) 细胞,淋巴蛋白激活杀手 (LAK) 细胞,γδ T细胞和树突细胞疫苗接种.
- 包括新的方法,如CAR巨细胞,树突细胞-细胞因子诱导的杀伤细胞,和调节性CAR-T细胞.
主要成果:
- 已建立的细胞疗法,如CAR T细胞,在临床前和临床早期的RCC环境中表现有前途.
- 新兴的策略,如CAR NK细胞和树突细胞疫苗接种,为RCC治疗提供了替代途径.
- 目前正在进行的研究正在扩大细胞治疗的范围,包括新的细胞类型和修饰.
结论:
- 细胞疗法是实现细胞癌 (RCC) 治愈的有希望的前沿,特别是晚期疾病.
- 持续的临床前开发和临床转化各种细胞疗法模式对于推进RCC治疗至关重要.
- 探索 CAR 巨细胞和调控性 CAR-T 细胞等创新方法可能进一步提高 RCC 的治疗疗效.
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