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Updated: Jul 6, 2025

Characterization of Glycoproteins with the Immunoglobulin Fold by X-Ray Crystallography and Biophysical Techniques
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Published on: July 5, 2018

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在GC衍生的B细胞系中,IgG-B细胞受体功能不需要N-链接的Fc糖化

Theresa Kissel1, Veerle F A M Derksen2, Arthur E H Bentlage3

  • 1Department of Rheumatology, Leiden University Medical Center, 2333 ZA, Leiden, The Netherlands. T.Kissel@lumc.nl.

Nature communications
|January 9, 2024
PubMed
概括

对IgG片段结晶 (Fc) 区域的糖化控制了抗体效应器功能,但没有影响B细胞受体 (BCR) 激活. 这表明Fc甘氨酸调节抗体功能,而不是B细胞激活.

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