在一般人群中,慢性呼吸道疾病的2型炎症和肺功能下降
Yunus Çolak1,2,3, Shoaib Afzal2,3,4, Jacob Louis Marott5
1Department of Respiratory Medicine, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark.
Thorax
|January 9, 2024
概括
2型炎症,以高血型乙酸盐 (BE) 和呼出的氧化 (FeNO) 表示,与慢性呼吸道疾病患者的肺功能下降速度更快有关. 这种效应在喘类疾病中最为显著.
科学领域:
- 肺部医学 肺部医学
- 免疫学 免疫学 免疫学
- 流行病学 流行病学
背景情况:
- 2型炎症与喘和COPD中的肺功能下降之间的关系尚未得到充分理解.
- 2型炎症,其特征是血中乙酸盐 (BE) 和呼出的氧化 (FeNO) 分数的升高,是某些呼吸道疾病的关键特征.
研究的目的:
- 调查2型炎症标志物 (BE和FeNO) 与普通人群肺功能下降率之间的关联.
- 为了确定升高的BE和FeNO是否预测1秒内强迫呼气体积的加速下降 (FEV1).
主要方法:
- 来自哥本哈根一般人口研究的数据分析,包括15605名BE参与者和2853名FeNO参与者.
- 在10年内评估1秒内强迫呼气体积 (FEV1) 的下降.
- 将参与者分为不同的呼吸道疾病类别:没有呼吸道疾病,完全可逆性喘 (AR),持久性阻塞性喘 (APO),COPD和不可分类的空气流限制 (NAL).
主要成果:
- 每年FEV1的下降幅度随着BE和FeNO水平的提高而显著增加.
- 具有高BE (≥300细胞/μL) 和FeNO (≥20ppb) 的参与者显示FEV1下降速度最快 (27毫升/年).
- 2型炎症和加速FEV1下降之间的关联在喘类表型 (AR) 中最为明显.
结论:
- 血中乙氨基和FeNO的升高,即2型炎症的指标,与慢性呼吸道疾病患者的FEV1下降加速有关.
- 这种关联在具有喘样表型的个体中尤为强烈,这表明2型炎症在疾病进展中起着作用.
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