暴露于PFDeA与高血压的关联 (NHANES, 2013-2018)
Jie Li1, Suling Ye1, Zeyuan Zhao1
1Department of Cardiology, The Second Affiliated Hospital of Dalian Medical University, Dalian, China.
perfluoroalkyl 和 polyfluoroalkyl 物质 (PFAS) 与健康问题有关. 这项研究发现, perfluorodecanoic acid (PFDeA) 暴露与非西班牙裔美国人的高血压风险和血压相关.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 流行病学 流行病学
背景情况:
- perfluoroalkyl 和 polyfluoroalkyl 物质 (PFAS) 是广泛使用的合成化学物质,已知其对健康的影响.
- 关于各种PFAS与高血压之间的特定联系的研究仍然有限.
- 了解这些关联对于评估公共卫生风险至关重要.
研究的目的:
- 调查不同类型的PFAS与高血压患病率之间的关联.
- 探索PFASs与静缩和静缩血压之间的关系.
- 检查PFAS与高血压相关的种族差异.
主要方法:
- 使用多变量逻辑回归来评估PFAS和高血压的患病率.
- 线条平滑图和线性回归分析了PFAS与血压的关系.
- 进行了按种族分层的子组分析.
主要成果:
- 在血清PFDeA度和高血压患病率 (OR=1.2,P=0.01) 之间发现了显著的正相关性.
- 其他PFAS与高血压没有显著关联.
- 血清PFDeA与非西班牙裔个体不服用抗高血压药物的静缩和静缩血压有积极联系.
结论:
- PFDeA暴露与非西班牙裔美国人的高血压有关.
- 在特定人群中,PFDeA可能会导致血压升高.
- 需要进一步的研究来阐明PFDeA暴露的机制和更广泛的影响.
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