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Updated: Aug 1, 2026

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
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设计和评价的PROTACs向基蛋白化酶1的设计和评估

Luís A R Carvalho1,2, Bárbara B Sousa1,2, Daniel Zaidman1

  • 1Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW.

Chembiochem : a European journal of chemical biology
|January 10, 2024
PubMed
概括

计算软件PRosettaC通过建议最佳的基链接剂来向乙蛋白化酶1 (APT1),提高药物发现效率,有助于设计蛋白质溶解向金马 (PROTACs).

关键词:
基于活动的蛋白质分析.生物信息学是一种生物信息学.点击"化学"就可以了.这就是 PROTACs.蛋白质组学是指蛋白质组学.

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Tail-anchored, or TA, proteins are estimated to make up to 3-5% of membrane proteins found in the eukaryotic cell. Such proteins have a single transmembrane domain located approximately 30 amino acid residues upstream from the C-terminal end. As a result, the signal recognition particle (SRP) cannot guide a TA protein to the ER membrane for cotranslational insertion. Hence, they are integrated into the ER membrane post-translationally using their C-terminal end as the anchor. TA proteins...