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微泡生物界面通过调节在急性血栓形成的气液界面的血小板膜表面活性剂的活动,以向急性血栓形成

Jiahui Wang¹, Weikui Jin², Shengyu Huang¹

¹Key Laboratory for Organic Electronics and Information Displays & Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Nanjing University of Posts and Telecommunications, Nanjing, 210023, P. R. China.

Angewandte Chemie (International ed. in English)

|January 10, 2024

概括

研究人员通过优化蛋白质-脂质比率以提高稳定性和超声波成像来开发出血小板启发的微泡 (PMB). 这些新型的PMB显示出对诊断诸如血栓形成等疾病的前景.

科学领域:

生物材料科学生物材料科学
纳米技术纳米技术
医疗成像医学成像

背景情况:

建立了具有细胞膜的功能化纳米粒子和纳米纤维.
由于脂质单层结构和低表面活性剂活性,微泡功能化很困难.

研究的目的:

开发一种策略来调节血小板膜囊泡的表面活性,以实现微泡功能.
为分子超声波成像创建稳定和功能性的微泡.

主要方法:

合成脂与血小板膜囊泡融合,以创建具有优化的蛋白质与脂质比率的"血小板体".
在气液接口上组装的平板体以稳定微气泡 (PMB).
评估了PMB的稳定性,循环,功能和超声波成像性能在体外和体内.

主要成果:

血小板微泡 (PMBs) 保留了61.4%的血小板蛋白和活性整合素αIIbβ3.
PMBs表现出卓越的稳定性,长时间的循环和卓越的体外/体内功能.
分子超声波成像显示,对于瘤区分而言,信号与噪声比提高了多达11.8dB.

结论:

表面张力调节策略使微气泡与细胞膜进行生物界面.
PMB为构建用于疾病诊断的分子超声波对比剂提供了一种新的方法.

关键词:

微泡生物界面的微泡生物界面血小板膜血小板膜表面张力调节的规则血栓形成的原因之一是血栓形成.超声波治疗学超声波治疗学

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