制药污染改变了细菌感染的成本及其与病原体负载的关系
Lucinda C Aulsebrook1, Bob B M Wong1, Matthew D Hall1
1School of Biological Sciences, Monash University, Melbourne, Victoria 3800, Australia.
Proceedings. Biological sciences
|January 10, 2024
概括
制药污染,像fluoxetine一样,改变了病原体的毒性和宿主-病原体的权衡. 这项研究表明,即使在低度下,环境污染物也可以改变病原体对宿主健康的影响.
科学领域:
- 生态学和进化生物学.
- 环境毒理学环境毒理学
- 微生物病原体的产生
背景情况:
- 宿主-病原体动态是由病原体扩散和宿主感染成本之间的平衡所塑造的.
- 对于新出现的污染物,如制药污染物,如何影响这种关键关系的理解有限.
- 素 (Prozac) 是一种常见的精神活性污染物,在自然水道中发现.
研究的目的:
- 研究素暴露对病原体扩散和毒性之间的关系的影响.
- 确定素如何改变病原体生长和它对宿主造成的损害之间的权衡.
- 通过*Daphnia magna*和*Pasteuria ramosa*模型系统来评估这些影响.
主要方法:
- 暴露在不同度的Daphnia magna中.
- 被感染的暴露水感染了细菌病原体 *Pasteuria ramosa*.
- 量化了病原体子负载和测量了宿主健康成本 (生育能力,生长) 跨越不同的素水平和宿主基因型.
主要成果:
- 素显著改变了Pasteuria ramosa的毒性,影响了宿主健康指标,如生育能力和生长.
- 平均病原体子负载的变化很小,这表明素主要改变了毒性的表达,而不是病原体的复制.
- 病原体扩散和毒性之间的权衡被fluoxetine重塑,其影响因污染物度和宿主基因型而异.
结论:
- 制药污染,即使是微量污染,也可以显著改变病原体的毒性和基本的宿主-病原体适应性权衡.
- 环境污染物可以改变宿主-病原体相互作用的生态和进化动态.
- 这项研究强调了需要考虑制药污染物对野生动物健康和生态系统功能的影响.
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