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牙周炎的调解者补充神经疾病的发展

Ayesha Sadiqa¹, Munsara Khalid Khan²

¹Ayesha Sadiqa, BDS, M.Phil., Ph.D. Associate Professor, Department of Physiology, CMH Lahore Medical College and Institute of Dentistry, Lahore, Pakistan.

Pakistan journal of medical sciences

|January 10, 2024

概括

慢性牙周炎与阿尔茨海默氏症和抑郁症等神经系统疾病有关. 特定的细胞因子,神经和细菌调解这种联系,恶化认知状况.

科学领域:

口腔健康口腔健康
神经学神经学
免疫学免疫学免疫学

背景情况:

牙周炎是一种常见的口腔疾病,越来越多地被认为与全身和神经疾病有关.
了解这些联系对于公共卫生至关重要.
在牙周炎-神经疾病途径中特定调解者的作用需要进一步阐明.

研究的目的:

调查细胞因子,神经和病原体在慢性牙周炎和神经疾病之间的关联中的中介作用.
总结与慢性牙周炎相关的神经系统疾病及其行为影响.

主要方法:

进行了全面的文献审查.
搜索的数据库包括PMC,科学直接,PubMed,研究门和谷歌学者.
搜索涵盖了从2022年10月到2023年2月的五个月时间.

主要成果:

慢性牙周炎与阿尔茨海默病,精神病,压力,焦虑,痴呆,严重抑郁症和糖尿病外围神经病变有关.
关键的介导因素包括细胞因子 (IL-6,IL-1,TNF-α,CRP),神经 (IGF-2,NPY,P物质) 和病原体 (P. gingivalis,T. forsythia,T. denticola).
这些媒介可以加剧相关的神经元和认知病理.

结论:

特定的细胞因子,神经和细菌病原体在调解慢性牙周炎和神经疾病之间的联系方面发挥着重要作用.
管理牙周炎可能对减轻某些神经疾病的风险或严重程度很重要.

关键词:

慢性牙周炎慢性牙周炎细胞因子 (cytokines) 是一种细胞因子.炎症调解者是指炎症调解者.身体感官障碍身体感官障碍和化学物质和化学物质.

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