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重编程短链脂肪酸新陈代谢减轻了Streptococcus pyogenes死性皮肤感染的组织损伤

Michael Caparon¹, Wei Xu¹, Tara Bradstreet¹

¹Washington University School of Medicine.

Research square

|January 10, 2024

概括

菌 pyogenes 使用发酵来抑制炎症,延迟愈合. 抑制这种细菌通路可以减少感染期间的组织损伤,提供一种新的治疗方法.

科学领域:

微生物学微生物学
免疫学免疫学免疫学
生物化学生物化学

背景情况:

疾病耐受性 (DT) 在感染期间限制宿主损伤,而不会伤害病原体.
杆菌pyogenes通过有氧混合酸发酵 (ARMAF) 和酸脱酶 (PDH) 操纵DT,以影响IL-10的表达.
在DT通路中调解宿主通信的特定微生物分子是未知的.

结论:

斯氏菌使用ARMAF来抑制宿主炎症反应,以牺牲宿主组织损伤为代价促进其生存.
细菌短链脂肪酸 (乙酸,甲酸) 是这种免疫逃避策略的关键调解者.
抑制细菌的pyruvate脱酶为缓解S. pyogenes感染中的组织损伤提供了一个有希望的治疗途径.

关键词:

在HDAC的基础上,HDAC是在 IL-10 中,IL-10 是 IL-10 的代表.链球菌是一种链球菌.发酵发酵发酵发酵巨细胞是一个巨细胞.中性粒细胞中性粒细胞.短链脂肪酸 - 短链脂肪酸皮肤感染皮肤感染.这是一种治疗疗法.

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