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蛋白质衰老时钟 (PAC) 预测了中年和老年人与年龄相关的结果

Chia-Ling Kuo^1,2,3, Zhiduo Chen³, Peiran Liu²

¹Department of Public Health Sciences, University of Connecticut Health Center, Farmington CT, USA.

medRxiv : the preprint server for health sciences

|January 10, 2024

概括

我们开发了一种蛋白质衰老时钟 (PAC),用于测量生物年龄和预测死亡风险. 这种新型的衰老生物标志物准确预测所有原因的死亡率和疾病发病率,帮助预防性医疗保健策略.

科学领域:

衰老的生物标志物
蛋白质组学是指蛋白质组学.
老年治疗的药物治疗.

背景情况:

生物衰老是复杂的,需要超出简单预后的先进生物标志物.
老年治疗需要可靠的工具来评估生物年龄和治疗疗效.

研究的目的:

开发一种蛋白质衰老时钟 (PAC),作为生物年龄的代理.
评估PAC预测所有原因死亡风险和疾病发病的能力.

主要方法:

利用了英国生物银行Pharma Proteomics项目数据 (53,021名参与者,2,923个血蛋白).
雇员LASSO惩罚了考克斯回归和戈珀茨模型来构建PAC.
与时间学年龄相关联的PAC蛋白质年龄 (斯皮尔曼相关性=0.77).

主要成果:

开发了一个强大的PAC预测所有原因死亡率 (10.9%死亡率超过13.3年).
美国农产品制造商 (PAC) 对死亡率和各种疾病发病的年龄调整显示出强烈的关联.
与PAC相关的蛋白质富含了生物衰老过程的标志.
通过PAC测量的年龄加速强烈预测死亡率和发生疾病,包括在没有疾病的个体中.

结论:

蛋白质衰老时钟 (PAC) 作为生物年龄的宝贵替代品.
PAC有效地预测所有原因的死亡率和疾病发病率,支持预防医学.
PAC促进了对多种疾病的早期风险评估,特别是在没有疾病的人群中,有助于个性化预防战略.

关键词:

生物年龄是生物年龄.芬诺时代 (PhenoAge) 是一个英国生物银行制药蛋白质组学项目加快了生物衰老的速度.生物年龄偏差偏差复合的衰老生物标记物.白细胞端粒的长度是什么

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