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控制的初级甲状腺功能低下症和健康患者之间的温度差异:一项探索性研究.
Maria Elena Romero-Ibarguengoitia1,2, Arnulfo Garza-Silva1,2, Andrea Rivera-Cavazos1,2
1Escuela de Medicina, Vicerrectoría de Ciencias de la Salud, Universidad de Monterrey, 66238 San Pedro Garza García, Nuevo León, Mexico.
Journal of the Endocrine Society
|January 10, 2024
概括
接受levothyroxine (LT4) 治疗的受控甲状腺功能低下症 (PCH) 患者由于皮肤温度较低,仍然会经历寒冷不耐受. 这表明热生成适应能力受损,影响生活质量.
科学领域:
- 内分泌学 在内分泌学.
- 代谢过程中的代谢.
- 热调节 热调节 热调节
背景情况:
- 甲状腺功能低下症通常用勒沃甲状腺素 (LT4) 替代疗法治疗.
- 尽管接受了治疗,但一些患有甲状腺功能低下症的患者报告持续的感冒不耐受.
- 了解残留温度调节缺陷对于改善患者福祉至关重要.
研究的目的:
- 为了比较皮肤温度和温度感知患者与初级控制的甲状腺功能低下症 (PCH) 和健康的对照.
- 与对照组相比,评估PCH患者的生活质量.
主要方法:
- 测量了身体中部和外围区域的皮肤温度.
- 试验对象在受控环境中报告了温度感知.
- 使用ThyPRO-39问卷来评估生活质量.
主要成果:
- 与对照组相比,PCH患者的手掌皮肤温度显著降低 (P=0.046).
- 在PCH组和对照组之间,温度感知没有差异.
- PCH患者报告生活质量明显降低 (P < .001).
结论:
- 在LT4治疗中控制的甲状腺功能低下与热生成受损和较低的体温有关.
- 这些温度调节异常可能导致持续的寒冷不耐受和降低生活质量.
- 对荷尔蒙适应环境变化的进一步研究是必要的.
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