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Updated: Jul 6, 2025

Identification of Mouse and Human Antibody Repertoires by Next-Generation Sequencing

Identification of Mouse and Human Antibody Repertoires by Next-Generation Sequencing

Published on: March 15, 2019

基于蒙特卡洛的推理对抗体和TCR曲目进行调整

Josiah Couch¹, Rohit Arora¹, Jasper Braun¹

¹Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02215.

|January 10, 2024

概括

这项研究引入了一种更快的方法来分析免疫谱系序列,以确定疫苗接种状态. 新方法显著降低了最大模型的计算成本,使免疫学中更大规模的研究成为可能.

科学领域:

计算免疫学计算免疫学
统计建模统计建模
生物信息学是一种生物信息学.

背景情况:

最大的模型分析免疫谱系序列的疫苗接种状态.
目前的方法需要计算密集的分区函数计算 (约. 每个模型的10^10个序列).
这种密集的计算限制了这些模型的可扩展性.

结论:

这种新方法有助于在计算免疫学中进行更大规模的研究.
代表了基于能源的建模的宝贵进步.
提高了使用最大模型用于免疫谱系分析的实用性.

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T and B Cell Receptor Immune Repertoire Analysis using Next-generation Sequencing

T and B Cell Receptor Immune Repertoire Analysis using Next-generation Sequencing

Published on: January 12, 2021

Generating De Novo Antigen-specific Human T Cell Receptors by Retroviral Transduction of Centric Hemichain

Generating De Novo Antigen-specific Human T Cell Receptors by Retroviral Transduction of Centric Hemichain

Published on: October 25, 2016

相关概念视频

Diversity of Antigen Receptors

Diversity of Antigen Receptors

Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...