轮班工作对免疫系统的影响:叙述审查
Marianne Stenbekk Thorkildsen1, Lise Tuset Gustad1,2,3, Jan Kristian Damås1,4,5,6
1Gemini Center for Sepsis Research at Institute of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Trøndelag, Norway.
Sleep science (Sao Paulo, Brazil)
|January 10, 2024
概括
轮班工作可能会影响免疫反应和感染风险,但研究显示对免疫细胞和功能产生不一致的影响. 需要更多的研究来澄清轮班工作的临床相关性和机制.
科学领域:
- 免疫学 免疫学 免疫学
- 职业健康 职业健康 职业健康
- 时间生物学 时间生物学
背景情况:
- 轮班工作是一个日益严重的职业健康问题.
- 之前的审查强调了关于轮班工作对免疫系统的影响的知识差距.
- 上一次关于这个主题的综合性审查是在2016年发表的.
研究的目的:
- 综合最近关于轮班工作对免疫反应影响的研究.
- 自2016年以来,确定文献中的新兴趋势和不一致性.
主要方法:
- 在PubMed,Scopus和Embase数据库中的系统文献搜索.
- 包括2016年以后发表的研究,重点关注轮班工作和免疫参数.
- 对13项新发现的研究进行分析.
主要成果:
- 关于轮班工作对免疫细胞和细胞因子的影响的不一致的发现.
- 观察到对昼夜节律,自我报告的感染和疫苗反应的影响的变化.
- 目前的证据表明,轮班工作对免疫系统的潜在影响.
结论:
- 轮班工作对免疫力的临床意义和潜在机制尚不清楚.
- 建议采用纵向设计和客观测量的进一步研究.
- 未来的研究应该集中于阐明轮班工作和免疫功能之间的确切关系.
相关概念视频
Factors Affecting the Risk of Infection
11.8K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
11.8K
Circadian Rhythms and Gene Regulation
4.1K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.1K
Psychoneuroimmunology: Cardiovascular Disease
31
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
31
Insufficient Sleep and Sleep Deprivation
145
Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
Sleep deprivation is a more severe form of sleep loss...
145
Psychoneuroimmunology: Diabetes and Cancer
29
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
29


