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在儿科创伤中使用全血:叙述性审查
Elissa Abou Khalil1, Katrina M Morgan1, Barbara A Gaines1,2
1Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Trauma surgery & acute care open
|January 10, 2024
概括
冷藏,低位数O组全血 (LTOWB) 越来越多地用于创伤复苏. 研究表明,LTOWB在儿科创伤患者中是安全有效的,改善了治疗结果和生存率.
科学领域:
- 紧急医疗 紧急医疗
- 输血医学 输血医学
- 儿科重症监护中心儿童重症监护中心
背景情况:
- 均衡的静血复苏改善了创伤患者的治疗结果.
- 冷藏,低位数O组全血 (LTOWB) 提供快速,平衡的复苏,并提供保存血小板等额外好处.
- 在儿科创伤中使用LTOWB正在增长,但尚未成为标准实践.
研究的目的:
- 审查关于LTOWB在儿科创伤中的使用现有文献.
- 评估LTOWB在儿科患者中的安全性和有效性.
主要方法:
- 对七项涉及儿科创伤队伍的研究进行了系统审查.
- 分析安全指标,如血液溶解和输血反应.
- 评估临床结果,包括冲击解消,凝血病,器官衰竭和生存.
主要成果:
- 儿科创伤患者的LTOWB输血没有导致血液溶解或急性输血反应.
- 在LTOWB接受者和对照者之间观察到相似的器官衰竭率.
- 益处包括更快地解决休克和凝血病,减少血液产品体积,并增加大量输血患者的存活率.
结论:
- LTOWB是一种安全且可能有益的儿童创伤复苏产品.
- 目前的证据受到小样本大小和单中心研究的限制.
- 多中心随机对照试验是必要的,以证实这些发现.
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