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感应受体通过调节肠道微生物群来缓解由内毒性引起的肠道损伤

Yan Sun¹, Jiayu Song², Huiying Liu³

¹Department of Neonatology, The First Affiliated Hospital of Harbin Medical University, Harbin, China.

Translational pediatrics

|January 10, 2024

概括

在新生小鼠中激活感应受体 (CaSR) 改善了肠道微生物群的多样性,并减轻了肠道损伤. 这表明CaSR调制是新生儿肠道疾病的潜在治疗策略.

科学领域:

微生物学微生物学
新生儿科学新生儿科学
胃肠病学胃肠病学

背景情况:

肠道微生物群越来越多地与新生儿疾病有关.
感应受体 (CaSR) 调节平衡,并且存在于肠道中.
CaSR可能会影响肠道微环境的组成和平衡.

研究的目的:

研究CaSR在调节新生小鼠肠道微生物群和肠道损伤中的作用.
确定CaSR激活和抑制对肠道微生物群组成和肠道健康的影响.

主要方法:

新生小鼠被分配到对照,脂聚糖化物 (LPS),CaSR激动剂或CaSR抑制剂组.
干预后24小时和7天收集了肠道内容.
16S rRNA测序分析了肠道微生物群的丰富性,多样性和种群丰富性.

主要成果:

低血压症加剧了肠道损伤;CaSR激动剂治疗减轻了损伤,而抑制剂加剧了损伤.
CaSR激活增加了肠道微生物群的多样性和乳酸菌的丰富性.
通过CaSR调制观察到细菌类 (Firmicutes, Bacteroidetes) 和属 (Akkermansia) 的显著变化.

结论:

CaSR的激活增强了肠道微生物群的物种丰富性和β多样性.
通过CaSR激活调节肠道微生物群可以减轻LPS诱导的肠道损伤.
在调节肠道微生物群和减轻新生儿肠道炎症方面,CaSR发挥着重要作用.

关键词:

我们的肠道微生物群.感应受体 (CaSR) 是一种感应受体.结尾性毒性病 (endotoxemia) 是一种导致内毒的疾病.高通量测序的高通量测序脂多糖 (LPS) 是一种脂多糖.

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