在微流体设备中收集和处理汗水和间歇液体
Tamoghna Saha1, Sneha Mukherjee1, Michael D Dickey1
1Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC 27695, USA. tsaha@ucsd.edu.
Lab on a chip
|January 10, 2024
概括
微流体设备提供先进的汗水和间歇液体 (ISF) 传感. 本次审查侧重于管理这些生物流体的微流体原理,旨在推进个性化医疗监测.
科学领域:
- 生物医学工程 生物医学工程
- 分析化学 分析化学
- 可穿戴技术可穿戴技术
背景情况:
- 自2010年代中期以来,微流体设备已出现用于汗水和间歇性液体 (ISF) 传感.
- 原型使用各种材料 (,聚合物,纸张,纤维) 进行生物流体的运输和操纵.
- 目前的设备主要专注于检测出汗率,电解质和代谢物.
研究的目的:
- 审查微流体在汗水和ISF管理和运输中的应用.
- 专注于管理生物流体生成,运输,提取和管理的基本微流体原则.
- 确定将微流体原型转化为临床应用和个性化医疗保健的挑战和前景.
主要方法:
- 对生物流体传感的微流体设备现有文献的审查.
- 分析微流体原理,包括流量控制,表面形态和蒸发.
- 讨论从实验室测试到临床试验的设备开发.
主要成果:
- 许多微流体原型已经开发用于体外,体外和体内传感.
- 有效控制流体流动,通道表面和蒸发,使样品管理成为可能.
- 有限数量的设备已经进入临床试验和商业化.
结论:
- 微流体显示出在可穿戴传感器中汗水和ISF管理的巨大潜力.
- 需要进一步发展,以克服临床翻译和商业化方面的挑战.
- 专注于微流体原理可以加速个性化医疗监测系统的发展.
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