在印度专业牙科期刊上发表的随机对照试验的评估,用于统计测试基线差异:一项超流行病学研究
Mahesh R Khairnar1, P G Naveen Kumar1, Ananta Kusumakar1
1Department of Public Health Dentistry, Faculty of Dental Sciences, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.
概括
许多牙科随机对照试验 (RCT) 错误地使用显著性测试进行基线比较,并且未能在表中报告基线特征,尽管有CONSORT指南. 这种做法在印度牙科专业期刊中仍然存在.
科学领域:
- 牙科研究 牙科研究
- 临床试验方法论 临床试验方法论
- 生物统计学 生物统计学
背景情况:
- 随机对照试验 (RCT) 通常使用显著性测试来比较干预组之间的基线差异.
- 这种做法受到研究人员和CONSORT等报告指南的广泛批评.
研究的目的:
- 为了确定印度牙科RCT基线比较的显著性测试的频率.
- 评估在这些研究中的表格中报告基线人口和临床特征.
主要方法:
- 2017年至2021年间在印度九个牙科专业期刊上发表的RCT的系统审查.
- 对326个RCT进行分析,以评估统计实践和数据呈现.
主要成果:
- 在分析的RCT中,45.4%的基线比较中使用了显著性测试.
- 显著多数 (72.7%) 的RCT未能在表中呈现出基线人口和临床特征.
结论:
- 尽管受到批评,但在印度牙科专业期刊中,使用显著性测试进行基线比较仍然很普遍.
- 在RCT中,始终没有遵守关于基线数据呈现的报告标准.
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