使用氧气进行急性血管扩张测试对由于左心病引起的肺高血压的影响
Sundararaj Rajkumar1, Ajay Kumar Jha1, Satyen Parida1
1Department of Anesthesiology and Critical Care, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
高流氧 (100%的微分吸入氧) 降低了肺动脉压力和阻力,因为心脏膜疾病的肺高血压的患者. 这种效应在结合的毛细血管前后和隔离的毛细血管后肺高血压表型中观察到.
科学领域:
- 心脏病学 心脏病学
- 肺部医学 肺部医学
- 麻醉学 麻醉学
背景情况:
- 由于心脏膜疾病 (PH-VHD) 的肺高血压具有复杂的血液动力学.
- 之前对包括氧气在内的肺血管扩张剂的研究,对于PH-VHD.产生了不一致的结果.
研究的目的:
- 评估100%微分启发氧 (FiO2) 对肺和全身血液动力学的影响.
- 为了评估这些影响的患者,结合前和后毛囊性肺高血压 (CpcPH) 和孤立后毛囊性肺高血压 (IpcPH) 由于PH-VHD.
主要方法:
- 涉及PH-VHD患者进行门手术的前性研究.
- 血液动力学变量测量在30%和100%的FiO2后麻醉和肺动脉导管.
- 患者分为响应者 (肺动脉平均压力下降≥10 mmHg) 和非响应者.
主要成果:
- 在100%的FiO2.2,肺动脉平均压力 (MPAP) 和肺血管阻力 (PVR) 的显著降低.
- 经肺梯度 (TPG) 和透气肺梯度 (DPG) 显著下降.
- 心脏输出没有显著变化;CpcPH和IpcPH表型之间具有可比的血液动力学改善.
结论:
- 过氧 (100% FiO2) 可能会降低CpcPH和IpcPHPHPH-VHD表型中的MPAP和PVR.
- 需要进行更大规模的研究来证实这些发现及其临床影响.
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