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Updated: Jul 6, 2025

Combining Chemical Cross-linking and Mass Spectrometry of Intact Protein Complexes to Study the Architecture of Multi-subunit Protein Assemblies
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Published on: November 28, 2017

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推进PROTAC的表征:通过ADDUCT和多式联动MS策略进行结构洞察

Mohammed Rahman1,2, Bryan Marzullo1, Stephen W Holman3

  • 1Department of Chemistry, University of Warwick, Coventry, CV4 7AL, U.K.

Journal of the American Society for Mass Spectrometry
|January 10, 2024
PubMed
概括

这项研究开创了针对蛋白质溶解向合体 (PROTACs) 的双重质谱 (MS) 分析,揭示了对于这些治疗分子的特征至关重要的碎片化模式.

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