精神生物调节纯素代谢,影响宿主的情绪行为
Xin Qian1,2, Jiahao Jiang1,2, Bo Yang1,2
1State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, Jiangsu 214122 P. R. China.
Journal of agricultural and food chemistry
|January 10, 2024
概括
精神病菌,特别是Bifidobacterium breve CCFM1025,可以调节大脑的纯素代谢和腺受体. 这种调节有助于降低压力诱导的丁和丁水平,潜在地改善情绪健康.
科学领域:
- 微生物学 微生物学
- 神经科学是一个神经科学.
- 代谢途径 代谢途径
背景情况:
- purin代谢对生物过程至关重要,影响大脑功能和情绪调节.
- 肠道微生物群的相互作用为理解和影响情感福祉提供了新的途径.
研究的目的:
- 调查Bifidobacterium breve CCFM1025在调节纯素代谢中的作用.
- 探索基因编辑益生菌在影响大脑功能和情绪反应方面的潜力.
主要方法:
- 利用基因编辑的益生菌和伪无细菌的小鼠模型.
- 进行了转录基因分析,以识别 purin代谢 (nrdB) 中的关键基因.
- 在体内比较野生型和nrdB突变型Bifidobacterium breve菌株.
主要成果:
- 确定了nrdB作为Bifidobacterium breve CCFM1025纯素代谢中的一个关键基因.
- 证明CCFM1025有能力降低血清和大脑中的山丁/山丁水平在压力小鼠.
- 观察到腺受体基因 (Adora2b) 的下调和微质激活的减少.
结论:
- 双细菌简短CCFM1025可以调节纯素代谢物和腺受体.
- 精神生物药物显示出通过肠-大脑轴路径调节情绪反应的潜力.
- 这项研究突出了连接肠道微生物群, purin代谢和情绪健康的新机制.
相关概念视频
Introduction to Biological Bases of Psychology
3.2K
Biopsychology serves as a vital bridge connecting the intricate domains of biology and psychology, shedding light on how biological systems influence psychological phenomena. This field scrutinizes the biological substrates of behavior and mental processes, emphasizing the nervous system along with the roles of neurotransmitters, hormones, and genetics. It also incorporates evolutionary perspectives to explain the adaptive nature of mental functions.
The nervous system, the cornerstone of...
The nervous system, the cornerstone of...
3.2K
Human Genetics
572
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
572
Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists
261
Serotonin, a crucial neurotransmitter synthesized by enterochromaffin cells, plays a cardinal role in regulating gastrointestinal (GI) motility. With over 90% of the body's total serotonin in the GI tract, its influence on digestive processes is profound. Serotonin is swiftly released upon various stimuli, such as food boluses or certain drugs, triggering intrinsic sensory neurons in the myenteric plexus and extrinsic vagal and spinal sensory neurons. This leads to the activation of the...
261
Hormonal Regulation
43.5K
Hormones regulate a significant portion of digestion through activation of the neuroendocrine system. The neuroendocrine system of digestion contains many different hormones all with multiple functions that are both, directly and indirectly, involved in digestion.
43.5K
An Overview of Psychoactive Drugs
235
Psychoactive drugs impact brain function, influencing perception, mood, consciousness, cognition, and behavior. These substances are grouped based on their effects and the mechanisms by which they act.
Stimulants such as cocaine, amphetamines, and nicotine enhance brain activity, leading to increased alertness, attention, and energy. These drugs typically raise heart rate, blood pressure, and body temperature. While they can induce feelings of euphoria, their misuse can result in severe health...
Stimulants such as cocaine, amphetamines, and nicotine enhance brain activity, leading to increased alertness, attention, and energy. These drugs typically raise heart rate, blood pressure, and body temperature. While they can induce feelings of euphoria, their misuse can result in severe health...
235
Psychoneuroimmunology: Cardiovascular Disease
31
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
31


