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在职业暴露的女性中长期保留和分配高缩

Sergey Y Tolmachev¹, Maia Avtandilashvili²

¹United States Transuranium and Uranium Registries, College of Pharmacy and Pharmaceutical Sciences, Washington State University, 1845 Terminal Drive, Suite 201, Richland, WA, 99354-4959, USA. stolmachev@wsu.edu.

Radiation and environmental biophysics

|January 10, 2024

概括

这项研究分析了职业暴露后31年女性组织捐赠者的分布. 主要保留在骨和脏中,在分布上没有观察到任何显著的基于性别的差异.

科学领域:

放射化学放射化学是指辐射化学.
核医学是一种核医学.
毒理学毒理学毒理学

背景情况:

职业接触高缩 (HEU) 需要了解其在人体中的长期分布和保留.
美国超和登记处 (USTUR) 收集全身组织样本,用于研究内部沉积的放射性核素.

研究的目的:

用放射化学方法量化一个职业接触HEU的女性组织中的分布.
将女性捐赠者的分布与男性捐赠者的现有数据进行比较.
评估当前用于剂量评估的生物动力学模型的准确性.

主要方法:

分析了来自已故女性捐赠者的全身组织样本 (n=129),记录了17年的职业HEU暴露.
进行放射化学分析以确定各种组织中的度.
在暴露后31年评估了的分布和保留,并与男性捐赠者的数据进行了比较.

主要成果:

在肺部 (16.5±2.0μg/kg) 和甲状腺 (6.3±2.9μg/kg) 发现的度最高.
骨架显示了最高的保留 (约. 40%),其次是脏 (大约). 30%),系统分布为骨架>大脑 ≈脏.
在女性和男性捐赠者之间没有观察到系统分布的显著差异.

结论:

在全身器官中的分布不均,并显示长期保留,特别是在骨中.
目前国际辐射保护委员会 (ICRP) 的生物动力学模型可能会大约20%高估大脑剂量评估.

关键词:

缩是一种缩.一个女人,一个女人.人的身体人的身体人的身体组织分析分析组织分析.这就是为什么我们要使用STUR.

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