血动脉动原体指数的升高与中风风险相关,一般中国人中风风险
Yijun Zhang1,2,3,4,5, Shuohua Chen6, Xue Tian1,2,3,4,5
1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Endocrine
|January 10, 2024
概括
血动脉质指数 (AIP) 的升高与中风和缺血性中风风险的增加有关. 这种关联适用于一般人群的基线和长期测量.
科学领域:
- 心血管流行病学心血管流行病学
- 心血管风险的生物标志物
背景情况:
- 血动脉生成指数 (AIP) 是心血管疾病 (CVD) 的一个建议标志物.
- 有限的纵向数据存在于AIP和中风风险之间的关联.
研究的目的:
- 调查基线和长期AIP水平与中风风险及其亚型之间的关联.
主要方法:
- 从Kailuan研究中分析了97,959名参与者,在基线时没有中风.
- AIP计算为日志{三糖/HDL-C);更新的平均AIP也计算.
- 考克斯比例危险模型用于评估中风风险,平均随访时间为12.79年.
主要成果:
- 较高的基线AIP四分位数与中风和缺血性中风 (IS) 风险增加相关.
- 在最高和最低AIP四分位数中,多变量调整后的中风HR为1.12.
- 在AIP和脑内出血 (ICH) 风险之间没有发现显著的关联.
结论:
- 基线和长期AIP的升高与中风和IS的更高风险有关.
- 在一般人群中,AIP似乎与ICH风险没有显著的关联.
相关概念视频
Blood Studies for Cardiovascular System III: Serum Lipid Profile
164
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
164
Cholesterol: Significance and Regulation
549
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Considering cholesterol and...
549
Psychoneuroimmunology: Cardiovascular Disease
31
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
31
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
93
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
93


