怀孕计划及其与自闭症谱系障碍的关联:探索早期发育研究的研究结果
Shericka T Harris1, Laura A Schieve2, Carolyn Drews-Botsch3
1National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, 4770 Buford Hwy NE, Mailstop S106-4, Atlanta, GA, 30341, USA. stharris@cdc.gov.
在非西班牙裔白人母亲中,怀孕计划与自闭症谱系障碍 (ASD) 相反相关. 在其他种族或民族群体中没有观察到这种关联,因为在这些群体中,规划不那么普遍.
科学领域:
- 生殖健康 生殖健康
- 神经发育障碍 神经发育障碍
- 围产期流行病学 围产期流行病学
背景情况:
- 自闭症谱系障碍 (ASD) 是一种复杂的神经发育状况.
- 了解影响自闭症风险的因素对于早期干预至关重要.
- 怀孕计划,这是生殖意图的衡量标准,已被探索为潜在的因素.
研究的目的:
- 调查怀孕计划与后代中自闭症发生之间的关联.
- 检查这种关联是否在种族和种族群体之间存在差异.
主要方法:
- 一项多站点病例控制研究 (Study to Explore Early Development - SEED) 招募了患有自闭症,其他发育迟缓 (DDs) 和普通人口 (POP) 的儿童.
- 母亲报告了怀孕计划 (怀孕的意图).
- 后勤回归被用来计算调整的赔率比率 (aORs),按种族-种族分层.
主要成果:
- 在非西班牙裔白人 (NHW) 母婴对中,怀孕计划与ASD (aOR=0.71) 和ASD症状 (aOR=0.67) 有反向关联.
- 在非西班牙裔黑人和西班牙裔母亲中,计划怀孕的频率较低.
- 在非西班牙裔黑人或西班牙裔母婴对中,没有发现怀孕计划和ASD或ASD症状之间的显著关联.
结论:
- 怀孕计划与ASD和ASD症状在NHW母婴双中相反相关.
- 在NHW母亲中,这种关联并不是由孕产妇或产周健康因素解释的.
- 观察到的关联是特定于NHW群体,不扩展到其他种族族群.
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