肠道微生物群和外围动脉疾病之间的因果关系的遗传支持:双向的门德尔随机化研究
Hongshuo Shi1, Xin Yuan1, Fangfang Wu1
1Department of Peripheral Vascular Surgery, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Aging
|January 10, 2024
概括
这项研究使用了门德尔的随机化来研究肠道微生物群.
科学领域:
- 微生物组研究 微生物组研究
- 遗传学 是一个遗传学.
- 心血管疾病流行病学
背景情况:
- 肠道微生物组成和外围动脉疾病 (PAD) 之间的确切关系仍然不完全理解.
- 调查潜在的因果关系对于理解PAD病原体至关重要.
研究的目的:
- 使用孟德尔随机化 (MR) 探索211种肠道微生物和外周动脉疾病 (PAD) 之间的潜在因果关系.
- 要确定这些因果关系是否是双向的.
主要方法:
- 通过使用来自MiBioGen和FinnGen联盟的全基因组关联研究 (GWAS) 总结统计数据进行了两样本的门德尔随机化 (MR) 分析.
- 进行了敏感性分析,以确保调查结果的可靠性.
- 用反向MR分析来评估潜在的反向因果关系.
主要成果:
- 该研究确定了9种特定的肠道微生物种群,与PAD有潜在的因果关系.
- 增加PAD风险与家族XI,属*Lachnoclostridium*和属*Lachnospiraceae*UCG001.1.的较高丰度有关.
- 对*Actinobacteria*类,*Acidaminococcaceae*家族,*Coprococcus2*属,*Ruminococcaceae*属UCG004,*Ruminococcaceae*属UCG010以及NB1n.n.序列,观察到与PAD风险的保护性关联.
结论:
- 这项MR研究提供了证据,支持特定肠道微生物群和PAD之间的因果关系.
- 这些发现确定了可能影响PAD风险的关键细菌种群,为未来的干预提供了潜在的目标.
- 在PAD和研究的肠道微生物群之间没有发现显著的反向因果关系.
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