相关实验视频

Updated: Jul 6, 2025

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

Published on: June 1, 2012

自热多级微针贴片用于皮肤癌局部治疗

Jundong Shao¹, Xingxing Li¹, Yashi Li¹

¹Marshall Laboratory of Biomedical Engineering, International Cancer Center, School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen University, Shenzhen, 518060, P. R. China.

Advanced materials (Deerfield Beach, Fla.)

|January 10, 2024

概括

一种新型的自我加热微针 (MN) 贴片增强了局部皮肤癌治疗. 这种贴片可以改善药物输送和透,提供高疗效和长期抑制瘤复发.

科学领域:

生物医学工程生物医学工程
材料科学材料科学材料科学
皮肤病学皮肤病学

背景情况:

针对皮肤癌的局部治疗面临着诸如药物输送不良,瘤透程度有限和血液循环不足等挑战.
微针 (MN) 技术提供了通过皮肤递送药物的潜力,但需要优化以提高治疗结果.

研究的目的:

开发和评估一种自我加热的微针 (MN) 贴片,以改善皮肤癌的局部治疗.
为了研究多层次的药物释放动力学和MN贴片的热增强.
评估MN贴片在体内治疗皮肤状细胞癌的疗效和安全性.

主要方法:

制造一个多层MN贴片,具有可溶解的底部用于快速释放和可降解的尖端用于持续释放.
加入一个自我加热的基板来增强药物扩散和透.
在体外和体内实验验验证热增强药物释放和治疗疗效.

主要成果:

自热的MN贴片显示了5-甲的快速释放和持续释放的thymoquinone.
热增强药物递送显著改善了瘤治疗疗效 in vivo.
在皮肤状细胞癌模型中,MN贴片显示出高疗效,低副作用和长期抑制复发.

结论:

开发的自我加热的MN贴片为皮肤癌的有效局部治疗提供了一个有希望的策略.
多级药物释放与热增强相结合,克服了传统局部治疗的局限性.
这种创新的MN贴片在治疗皮肤恶性瘤和预防复发方面具有临床翻译的潜力.

关键词:

药物输送是药物输送的过程.微针贴片微针贴片自动加热自动加热皮肤癌是皮肤癌.局部治疗治疗局部治疗

更多相关视频

Author Spotlight: Innovative Microneedle-Based Strategies for Enhanced Exosome Delivery and Stability

Author Spotlight: Innovative Microneedle-Based Strategies for Enhanced Exosome Delivery and Stability

Published on: July 12, 2024

Polymeric Microneedle Array Fabrication by Photolithography

Polymeric Microneedle Array Fabrication by Photolithography

Published on: November 17, 2015

相关概念视频

Skin Cancer

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

Clinical Applications of Epidermal Stem Cells

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...