用MDMA辅助治疗PTSD对自我体验的影响
Bessel A van der Kolk1, Julie B Wang2, Rachel Yehuda3,4
1Trauma Research Foundation, Brookline, MA, United States of America.
PloS one
|January 10, 2024
概括
在3期试验中,MDMA辅助疗法显著改善了自我体验和PTSD症状. 这种迷幻疗法提供了一种新的方法来治疗严重的创伤后应激障碍 (PTSD),通过提高情绪应对能力.
科学领域:
- 心理药理学 心理药理学
- 临床心理学 临床心理学
- 精神病学是一个精神病学.
背景情况:
- 对像3,4-甲基二氧化甲胺 (MDMA) 这样的迷幻物质的重新兴趣,用于治疗.
- 严重的PTSD通常与情绪应对和自我能力的缺陷有关,阻碍了治疗.
- 一项3期临床试验 (NCT03537014) 研究了MDMA辅助治疗严重的PTSD.
研究的目的:
- 评估MDMA辅助治疗与安慰剂在跨诊断结果措施上的差异效应.
- 探索自我体验的变化如何有助于改善PTSD症状得分.
- 评估MDMA辅助治疗对PTSD患者情绪应对和自我能力的影响.
主要方法:
- 随机,双盲,安慰剂控制,多地点的第三阶段试验.
- 参与者在3次实验性会议中接受了MDMA或安慰剂的手动治疗,再加上准备和整合访问.
- 在基线和治疗后2个月使用多伦多亚力西西米亚尺度 (TAS-20),自我同情度量 (SCS) 和自我能力变化的库存 (IASC) 测量症状.
主要成果:
- 与安慰剂相比,MDMA辅助疗法在TAS-20,SCS和大多数IASC因素上呈现出统计学上显著的更大改善.
- 在人际冲突,理想化,幻灭,放弃担忧,自我意识,影响调节等方面观察到改善.
- 该研究包括90名参与者,84.4%的人有发展性创伤史,87.8%的人经历过多重创伤.
结论:
- 用MDMA辅助治疗对跨诊断的自我体验过程产生了显著的积极影响.
- 这些自我体验的改善往往与创伤后应激障碍治疗的不良结果有关.
- 这些发现表明,像MDMA这样的迷幻药物可能促进心理能力,这对于减轻PTSD症状至关重要.
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