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个人尿液挥发性有机化合物和儿童肺功能之间的关联
Dawon Park1, Eun Kyo Ha2, Haeri Jung1
1Bundang CHA Medical Center, CHA University School of Medicine, Seongnam, Korea.
这项研究将儿童尿液中和代谢物含量较高与呼吸道功能较差联系在一起,特别是呼吸阻力增加 (Rrs5) 和FEV1/FVC比率降低,表明潜在的肺部健康影响.
科学领域:
- 环境健康 环境健康
- 儿科肺病学 儿科肺病学
- 毒理学 毒理学 毒理学
背景情况:
- 人为挥发性有机化合物 (VOC) 是可以对儿童呼吸系统健康产生负面影响的污染物.
- 研究尿液中的特定VOC代谢物与肺功能客观测量的联系对于了解暴露影响至关重要.
- 这项研究的重点是儿童暴露于常见的VOC如和.
研究的目的:
- 研究尿液挥发性有机化合物 (VOC) 代谢物与儿童呼吸道功能之间的相关性.
- 评估暴露于特定的VOC,如和,对儿童群体呼吸系统健康指标的影响.
- 为了确定尿中代谢物水平是否可以作为不良呼吸系统影响的生物标志物.
主要方法:
- 141名儿童的队列接受了皮肤刺伤测试,螺旋计,脉冲振荡计 (IOS),并提供尿样.
- 通过测量1秒内强制呼吸量 (FEV1),强制生命能力 (FVC) 和FEV1/FVC比率来评估气道功能.
- 用5 Hz (Rrs5) 和Rrs5-20的呼吸阻力来评估气道力学. 用气相色谱/并联质谱分析了和烯代谢产物的尿度.
主要成果:
- 尿液中粘氨酸 (代谢物) 的水平升高与Rrs5 (呼吸道阻力指标) 的增加显著相关.
- 高度的o-甲基hippuric 酸 (一个氧烯代谢物) 与增加的Rrs5和FEV1/FVC比率的下降相关.
- 没有发现Rrs5-20或FEV1与分析的VOC代谢物有显著的关联.
结论:
- 增加的和代谢物的尿液水平与儿童的不良气道机制有关,特别是更高的气道阻力和限制性肺部模式.
- 这些发现表明,尿液中的VOC代谢物可以作为因环境污染物暴露而导致呼吸系统受损的指标.
- 需要进一步的研究来探索儿童暴露于这些VOC的长期呼吸系统健康后果.
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