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相关概念视频

Preparation and Reactions of Thiols02:33

Preparation and Reactions of Thiols

6.2K
Thiols are prepared using the hydrosulfide anion as a nucleophile in a nucleophilic substitution reaction with alkyl halides. For instance, bromobutane reacts with sodium hydrosulfide to give butanethiol.
6.2K
Preparation and Reactions of Sulfides02:26

Preparation and Reactions of Sulfides

4.8K
Sulfides are the sulfur analog of ethers, just as thiols are the sulfur analog of alcohol. Like ethers, sulfides also consist of two hydrocarbon groups bonded to the central sulfur atom. Depending upon the type of groups present, sulfides can be symmetrical or asymmetrical. Symmetrical sulfides can be prepared via an SN2 reaction between 2 equivalents of an alkyl halide and one equivalent of sodium sulfide.
4.8K
Structure and Nomenclature of Thiols and Sulfides02:17

Structure and Nomenclature of Thiols and Sulfides

4.7K
Thiols and sulfides are sulfur analogs of alcohols and ethers, respectively, where the sulfur atom takes the place of the oxygen atom. Thus, thiols are generally represented as RSH, where R is an alkyl substituent and —SH is the functional group. On the other hand, in sulfides, the central sulfur atom is bonded to two hydrocarbon groups on either side. Depending upon the type of group, sulfides can be either symmetrical or asymmetrical. Both thiols and sulfides display a bent geometry,...
4.7K

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Synthesis and Bioconjugation of Thiol-Reactive Reagents for the Creation of Site-Selectively Modified Immunoconjugates
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含有的醇特异生物结合反应剂

Zhenguo Zhang1,2, Lanyang Li3, Hailun Xu3

  • 1College of Advanced Interdisciplinary Science and Technology, Henan University of Technology, Zhengzhou 450001, China.

Journal of the American Chemical Society
|January 10, 2024
PubMed
概括

一种基于的新型生物结合试剂为反应提供了增强的选择性. 这一进步改善了蛋白质结合和抗体-药物结合合成,为药物化学开辟了新的可能性.

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科学领域:

  • 化学生物学 化学生物学
  • 药用化学 医学化学
  • 材料科学 材料科学 材料科学

背景情况:

  • 传统的生物结合试剂往往缺乏选择性,可能容易发生反复反应.
  • 开发具有改进性能的新试剂对于推进蛋白质修饰和药物递送系统至关重要.

研究的目的:

  • 开发一种新的含生物结合试剂,用于选择性醇修饰.
  • 在化学选择性,产量和与生物分子的兼容性方面评估试剂的性能.

主要方法:

  • 合成一种新的含有的生物结合试剂.
  • 测试试剂与各种硫醇和不和碳烯化合物的反应性.
  • 评估由此产生的结合物的稳定性和生物相容性.

主要成果:

  • 试剂对硫醇具有很高的化学选择性,超过了传统试剂.
  • 反应在生物相容条件下进行,产量中等至高.
  • 由此产生的结合物与生物分子具有很好的稳定性,适用于抗体-药物结合物合成.

结论:

  • 新的基于的试剂提供了一种多功能和有效的工具,用于 thiol 特定的生物结合.
  • 它的特性使其在蛋白质修饰,抗体-药物联合合成和无机-有机混合材料中的应用成为可能.
  • 这项工作扩大了生物分析科学和药物化学研究人员的工具包.