可注射的网状导电凝贴片用于消除心房动
Jing Dai1, Bingfang Wang1, Zhiqiang Chang1
1Research Center for Translational Medicine, Key Laboratory of Arrhythmias of the Ministry of Education of China, Shanghai East Hospital, The Institute for Biomedical Engineering & Nano Science, Tongji University School of Medicine, Shanghai, 200120, China.
Advanced healthcare materials
|January 10, 2024
概括
一种新的灵活,导电的水凝心状贴片有效治疗心房动 (AF). 这种创新的可植入装置提供了一种最少的侵入性方法来调节心脏生物电信号并防止致命的心律失常.
科学领域:
- 生物材料科学 生物材料科学
- 心血管研究研究心血管研究
- 再生医学是一种再生医学.
背景情况:
- 心房动 (AF) 源于心房不规则的电脉冲,导致心律失常和心脏突然死亡.
- 目前的治疗方法,如药物和手术,存在身体损伤和高手术并发症的风险.
- 柔性和柔软的植入物为心脏疾病提供了一个有前途的新疗法策略.
研究的目的:
- 开发和评估一种基于水凝的导电性网状心脏贴片,用于消除心房动.
- 评估贴片的物理性质,生物相容性和调节心脏生物电信号的有效性.
主要方法:
- 制造一个灵活的,导电的水凝网格贴片,具有形结构.
- 评估贴片的弹性,符合性,弹性和形状记忆性质.
- 在活体动物中,微创地将贴片植入心房表面,持续一个月.
- 通过导电性和电荷储存能力 (CSC) 评估生物相容性,稳定性和AF消除功效.
主要成果:
- 网状补丁表现出了出色的灵活性,表面形状和变形合规性,适合心脏的表面并适应其运动.
- 该贴片在植入一个月后表现出良好的生物相容性和稳定性.
- 导电性水凝贴片有效地消除了AF,这是由于其导电性和高电荷储存能力.
结论:
- 导电性水凝网状心脏贴片是一种可行的,最少侵入性的治疗选择,用于治疗心房动.
- 这种方法为心脏生物电信号调制在心律失常疾病的管理中提供了新的可能性.
- 开发的贴片显示了未来临床应用在治疗心律障碍方面的潜力.
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