抗菌活性和体外毒性查的抗真菌药物复合与β-cyclodextrin
Gustavo Simão Moraes1, Nathaly Mayer Tozetto1, Thaynara Aparecida Alves Pedroso1
1Department of Dentistry, State University of Ponta Grossa, Ponta Grossa, Brazil.
Journal of applied toxicology : JAT
|January 10, 2024
概括
贝塔-环德林复合剂降低了尼斯塔丁和赫西丁抗真菌药物的毒性. 这些复合物可能提供一种更安全,生物相容的选择来治疗Candida感染.
科学领域:
- 药理学 药理学是指药理学的学科.
- 菌类学 菌类学是指菌类学.
- 材料科学 材料科学 材料科学
背景情况:
- 新兴的真菌耐药性和抗真菌药物毒性需要新的治疗策略.
- 循环德克斯含有复合物提供了增强抗菌活性和控制药物释放的潜力,并减少了副作用.
研究的目的:
- 为了评估nystatin (Nys) 和与β-cyclodextrin (βCD) 复合的 (Chx) 的体外抗真菌有效性和毒性.
主要方法:
- 使用Artemia salina生物试验进行毒性查.
- 通过汁微稀释来确定针对Candida albicans的最小抑制度 (MIC).
- 使用MTT和中性红色试验的细胞毒性评估,以及细胞形态分析.
主要成果:
- 与不复杂的形式相比,βCD复合的抗真菌药在A. salina生物试验中表现出较低的毒性.
- MIC值:Nys (0.5毫克/升),Nys:βCD (4毫克/升),Chx (4毫克/升),Chx:βCD (8毫克/升). 没有任何其他值.
- 赫西丁显示出显著的细胞毒性,而βCD复合物药物和尼斯塔丁显示出高细胞活力与最小的损伤.
结论:
- 与βCD的复合似乎可以降低尼斯塔丁和赫西丁的毒性.
- 与βCD复合的抗真菌剂为管理与Candida相关的感染提供了潜在的生物相容性替代品.
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