对BCG疫苗接种的先天性和适应性反应的多omics分析揭示了预测训练免疫力的表观遗传细胞状态
Simone J C F M Moorlag1, Lukas Folkman2, Rob Ter Horst3
1Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands.
Immunity
|January 10, 2024
概括
细菌卡尔梅特 - 格林 (BCG) 疫苗接种增强了特定个体的先天免疫反应,揭示了训练免疫力的变化. 这项研究确定了在大型人类队列中影响BCG免疫反应的遗传和表观遗传因素.
科学领域:
- 免疫学 免疫学 免疫学
- 遗传学 遗传学 是一个
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
背景情况:
- 免疫反应表现出显著的个体间变异性.
- 训练免疫力是一种先天免疫记忆的形式,可以通过像Bacillus Calmette-Guérin (BCG) 这样的疫苗来诱导.
研究的目的:
- 为了研究训练免疫力的人口变异.
- 为了确定BCG疫苗接种后免疫反应的遗传和表观遗传预测因素.
主要方法:
- 健康个体 (n=323) 用BCG进行免疫接种.
- 在90天内生成个人免疫概况和染色质可访问性地图.
- 进行了遗传和表观遗传分析,以与免疫反应相关联.
主要成果:
- 接种BCG疫苗诱导了训练有素的免疫力,个人之间存在显著差异.
- 遗传和表观遗传因素被确定为基线免疫和反应的预测因素.
- 增强的先天免疫反应被观察到,特别是在基线时具有休眠免疫状态的个体中.
结论:
- 在人群中,BCG疫苗接种的异质免疫刺激作用和训练免疫力有很大差异.
- 表观遗传状态对于将免疫功能与宿主基因型和环境因素联系起来至关重要.
- 了解个体免疫变异是优化疫苗策略的关键.
更多相关视频
相关概念视频
01:23Cells of the Adaptive Immune Response
989
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
989
01:24B Cell Activation and Differentiation
1.7K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
1.7K
01:51Vaccinations
44.5K
Overview
44.5K
01:31Defense Against Bacterial Pathogens
1.4K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
1.4K
01:20Special Features of Adaptive Immunity
822
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
822
01:40Cell-mediated Immune Responses
68.3K
Overview
68.3K