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Updated: Jul 6, 2025

Time-resolved Förster Resonance Energy Transfer Assays for Measurement of Endogenous Phosphorylated STAT Proteins in Human Cells
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Time-resolved Förster Resonance Energy Transfer Assays for Measurement of Endogenous Phosphorylated STAT Proteins in Human Cells

Published on: September 9, 2021

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使用机械到机器学习框架预测基因层面对JAK-STAT信号干扰的敏感性

Neha Cheemalavagu1, Karsen E Shoger2, Yuqi M Cao2

  • 1Department of Computational and Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Center for Systems Immunology, University of Pittsburgh, Pittsburgh, PA, USA.

Cell systems
|January 10, 2024
PubMed
概括

这项研究开发了一个计算模型,将Janus激酶 (JAK) -信号转换器和转录激活器 (STAT) 路径动态与基因表达联系起来. 该模型预测了细胞因子特异性基因反应和JAK2抑制的影响,有助于向治疗.

关键词:
抑制了JAK的发生.这就是JAK-STAT.细胞因子信号传递机器学习是机器学习.巨细胞是一个巨细胞.机械模型模型机械模型建模框架是一个建模框架.基于规则的建模.时间编码时间编码.转录因子的特异性

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