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超声响应的微气泡和纳米滴:一种通往向药物输送的途径

Gazendra Shakya1, Marco Cattaneo1, Giulia Guerriero1

  • 1Institute of Fluid Dynamics, D-MAVT, Sonneggstrasse 3, ETH Zurich, Zurich, 8092, Switzerland.

Advanced drug delivery reviews
|January 10, 2024
PubMed
概括

超声响应的微泡和纳米滴通过增加细胞透性来增强药物输送. 本综述详细介绍了它们的机制,效果和临床进展,强调了更广泛应用的挑战.

关键词:
血脑屏障 (Blood-Brain Barrier,BBB) 是一个很大的障碍.细胞通透性的细胞通透性.细胞内存症是指细胞内存症.增强的透性和保留效应 (EPR)微气泡是一种微气泡.这些纳米滴是纳米滴.通过超声波检测进行了超声波检测.

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Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
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