一种新的翻译性PET成像方法,用于定量远端瘤在向辐射治疗和检查点阻塞后的免疫激活
Yujun Zhang1, Jessy S Deshane2, Eddy S Yang3
1Graduate Biomedical Sciences, The University of Alabama at Birmingham, Birmingham, Alabama; Department of Radiology, The University of Alabama at Birmingham, Birmingham, Alabama.
International journal of radiation oncology, biology, physics
|January 10, 2024
概括
使用[68Ga]-NOTA-GZP的新型正子发射断层扫描 (PET) 成像可以在临床前癌症模型中非侵入性检测abscopal免疫激活并预测治疗反应.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 放射学 放射学是一门学科.
- 分子成像学分子成像学
背景情况:
- 无线免疫激活,一种在一个瘤上的放射治疗可以导致远程,非辐射瘤的回归的现象,是癌症治疗的一个有前途的领域.
- 非侵入性地量化这种免疫反应对于预测治疗疗效和指导治疗策略至关重要.
研究的目的:
- 开发和验证一种使用[68Ga]-NOTA-GZP正子发射断层扫描 (PET) 成像的新型非侵入性方法.
- 量化abscopal免疫激活,并预测涉及辐射和免疫检查点抑制剂的组合治疗的反应.
主要方法:
- 使用4T1乳腺癌和易斯肺癌 (LLC) 鼠标模型,瘤接受辐射和组合免疫疗法 (PD-1和CTLA-4抑制剂) 或对照.
- 对瘤生长进行了监测,并使用[68Ga]-NOTA-GZP PET成像评估细胞毒性T细胞活性标记物Granzyme B活性.
- 在基线和每3天进行一次PET成像,直到治疗后的第9天.
主要成果:
- 组合疗法在照射和非照射瘤中显著降低了瘤体积,表明了abscopal效应.
- 在第九天非辐射瘤中,高[68Ga]-NOTA-GZP PET信号在4T1和LLC模型中预测了治疗反应.
- 确定了特定的PET信号值,以准确预测治疗反应.
结论:
- [68Ga]-NOTA-GZP PET成像成功量化了非侵入性的abscopal免疫激活.
- 这种成像模式可以在可观察到的瘤体积变化之前预测治疗反应.
- 这些发现表明[68Ga]-NOTA-GZP PET在临床环境中的潜在翻译应用,以监测对组合疗法的免疫反应.
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