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慢性化学遗传抑制TRPV1膀 afferent促进SCI后的恢复

Long Ma¹, Chen Zhu¹, Yun-Fei Wei¹

¹Department of Urology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China.

Experimental neurology

|January 10, 2024

概括

脊髓损伤会影响膀的控制. 向TRPV1+膀神经,用素或化学遗传药物改善了膀功能,并减少了受伤后的超反射.

科学领域:

神经科学是一个神经科学.
泌尿器科泌尿器科泌尿器科泌尿器科
再生医学是一种再生医学.

背景情况:

脊髓损伤 (SCI) 经常导致膀控制的慢性丧失,其特征是膀反射过度和detrusor缩器失能.
素治疗在SCI模型和患者中减轻非排泄性膀收缩方面表现有希望,但其神经机制尚不清楚.

研究的目的:

在SCI之后,研究TRPV1+膀 afferent神经元的结构和功能变化.
阐明素对SCI后膀功能的治疗作用背后的神经机制.

主要方法:

逆行腺相关病毒 (RetroAAV) 注入膀壁以准TRPV1+膀附属神经元.
对神经元 soma 尺寸和脊髓轴突在 T8 脊髓压碎后生长的形态分析.
慢性化基因抑制表达TRPV1.1.的背部根结节神经元 (DRG).

主要成果:

脊髓损伤诱导了 soma 尺寸的边缘增加和 TRPV1+ 膀 afferent 神经元的显著脊髓轴突生长.
这些神经元的化学遗传抑制改善了排尿恢复,增加了排泄效率并减少了膀反射.
与SCI相关的形态变化在神经元抑制后减少.

结论:

TRPV1+膀附带神经元在SCI后经历了显著的结构和功能变化.
准这些神经元为改善脊髓损伤后膀功能提供了一个有希望的治疗策略.
这些发现支持素在临床上用于治疗SCI患者的膀功能障碍.

关键词:

阿克森芽的生长时间膀膀膀是一个化学遗传抑制化学遗传抑制这就是为什么DRG DRG.微观测试是一种微观测试.这就是SCI.在 TRPV1 中.尿动力学尿动力学尿动力学

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