老年人对抑郁症和药物变化的态度:一个集群随机对照试验的纵向子研究
Katharina Tabea Jungo1,2, Kristie Rebecca Weir3,4, Damien Cateau5,6
1Institute of Primary Health Care BIHAM, University of Bern, Bern, Switzerland katharina.jungo@protonmail.com.
BMJ open
|January 10, 2024
概括
年龄较大的患者.
科学领域:
- 老年医学 老年医学
- 药理学 药理学是指药理学的学科.
- 初级保健研究研究初级保健研究
背景情况:
- 多药性在患有多种慢性疾病的老年人中很常见.
- 降低处方的目的是减少药物负担并改善患者的治疗结果.
- 患者愿意停止处方是成功药物管理的关键因素.
研究的目的:
- 检查老年患者不再处方药的意愿与与药物相关的结果之间的联系.
- 评估患者态度对药物数量和适当性变化的影响.
- 确定患者对脱处方的同意是否会影响电子决策支持建议的实施.
主要方法:
- 一个纵向子研究的"优化药物治疗在多病老年人在初级CAre" (OPTICA) 试验.
- 包括65岁以上的患者,患有3种以上的慢性病和5种以上来自瑞士初级保健的常用药物.
- 通过使用修订的患者对处方态度 (rPATD) 问卷评估了患者的意愿,并分析了1年内的药物变化.
主要成果:
- 研究人员发现,人们担心停止服用药物和随着时间的推移使用更多药物之间存在显著的关联.
- 大多数患者对抑郁症和药物相关结果的同意措施之间没有发现显著的关联.
- 关于停止得分的担忧预测平均每单位增加0.65种药物的增加 (95%CI:0.08至1.22).
结论:
- 患者愿意放弃处方,特别是对戒药的担忧,与老年人药物相关结果的联系有限.
- 需要进一步的研究来了解影响抑郁症成功的复杂因素.
- 这项研究强调了对老年人药物管理的个性化方法的需要.
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