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Updated: Jul 6, 2025

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由于获得的PMS2突变,PD-L1+扩散型大B细胞淋巴瘤具有极高的突变负担和微卫星不稳定性

Andrew W Allbee1, James Gerson2, Guang Yang1

  • 1Division of Hematopathology, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

Cold Spring Harbor molecular case studies
|January 10, 2024
PubMed
概括

这项案例研究揭示了两个不同的扩散型大B细胞淋巴瘤 (DLBCLs) 在一个患者中,一个患者具有高突变负担和微卫星不稳定性 (MSI). 对于DLBCL患者,建议对PD-L1表达和MSI进行例行测试.

关键词:
在B细胞淋巴瘤.

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Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
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