尼尔马特里尔维尔/里托纳维尔对达鲁纳维尔血最低度没有影响:一个病例报告
Dario Cattaneo1, Simone Pagano2, Samuel Lazzarin2
1ASST Fatebenefratelli Sacco, Milan, Italy dario.cattaneo@asst-fbf-sacco.it.
European journal of hospital pharmacy : science and practice
|January 10, 2024
概括
作为COVID-19治疗方法的尼尔马特里尔维尔/里托纳维尔不会影响HIV患者在增强治疗方案中的达鲁纳维尔水平. 这一发现让医生放心,不要同时服用这些关键药物.
科学领域:
- 传染性疾病 传染性疾病
- 病毒学 病毒学
- 药理学 药理学是指药理学的学科.
背景情况:
- 对于携带艾滋病毒的人来说,COVID-19带来了重大风险.
- 尼尔马特里尔维尔/里托纳维尔是推的COVID-19治疗方法,可以安全地与大多数HIV抗逆转录病毒药物一起使用.
- 尼尔马特里尔维尔/里托纳维尔与增强型抗逆转录病毒疗法之间的相互作用,特别是涉及达鲁纳维尔,需要进一步调查.
研究的目的:
- 为了研究添加nirmatrelvir/ritonavir到含有darunavir的增强抗逆转录病毒治疗方案的药理动力学效应.
- 评估影响HIV阳性患者达鲁纳维尔血最低度的潜在相互作用.
主要方法:
- 病例报告详细介绍了一名艾滋病毒感染者接受增强抗逆转录病毒疗法 (达鲁纳维尔,里托纳维尔,科比西斯塔特) 的病例.
- 尼尔马特里尔维尔/里托纳维尔用于COVID-19治疗的使用.
- 在联合使用之前和期间监测达鲁纳维尔的血最低度.
主要成果:
- 添加涅马特里尔维尔/里托纳维尔并没有显著改变达鲁纳维尔的血最低度.
- 对于现有的抗逆转录病毒疗法,没有必要调整剂量.
结论:
- 从药理动力学角度来看,与基于达鲁纳维尔的增强疗法同时服用尼尔马特雷尔维尔/里托纳维尔似乎是安全的.
- 这一案例为临床医生提供了关于加强抗逆转录病毒疗法治疗艾滋病毒患者COVID-19的管理的保证.
- 避免不必要的治疗拒绝或药物停用.
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