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不充分的 (Ax) 跨支气管肺移植活检-范围和潜在的促成因素

Stylianos Kakoullis¹, Brandon Menachem², Katherine Young²

¹Internal/Pulmonary and Intensive Care Medicine, European University, Cyprus.

Transplantation proceedings

|January 10, 2024

概括

跨支气管活检对于肺移植评估至关重要,但通常会产生非诊断样本. 诸如先前的活检和呼吸道问题等因素增加了这种风险,需要仔细考虑样本的充分性.

科学领域:

肺部医学肺部医学
移植手术移植手术
病理学病理学病理学

背景情况:

跨支气管活检对于肺移植移植的评估和诊断急性细胞排斥至关重要.
在15-50%的病例中会出现非诊断性样本,导致重复手术.
导致非诊断性采样和支气管镜医生-病理学家差异的因素尚不清楚.

研究的目的:

确定与肺移植受体的非诊断性横支气管气膜采样相关的因素.
为了比较诊断和非诊断活检组之间的患者人口统计和程序特征.

主要方法:

对128名肺移植接受者进行了透视性队列研究,他们接受了带有活检的支气管镜检查.
对非诊断性气泡膜采样率的评估.
患者人口统计和程序特征的比较.

主要成果:

膜组织采样的不足率为15.5%.
增加不充分采样几率的因素包括先前的活检,先前的不充分样本,更多的传递尝试,呼吸道异常和全身麻醉.
病理学家从8个评估的样本中发现了6个适当样本的中位数.

结论:

特定的患者和程序因素预测过 bronchial 活检采样不足.
支气管镜医生可能会考虑获得额外的样本以提高诊断产量.
需要进行多中心研究,以进一步调查促成因素.

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