维生素D,欧米茄-3和简单的力量炼计划在预防心血管疾病方面的作用:DO-HEALTH随机对照试验
Stephanie Gaengler1, Angélique Sadlon2, Caroline De Godoi Rezende Costa Molino1
1Department of Geriatrics and Aging Research, University of Zurich, Zurich, Switzerland; Centre on Aging and Mobility, University of Zurich, Zurich, Switzerland.
The journal of nutrition, health & aging
|January 10, 2024
概括
这项研究发现,欧米茄-3脂肪酸,维生素D3和家庭力量炼并没有防止老年人发生重大心血管事件. 欧米茄-3脂肪酸改变了脂质生物标志物,但具有混合作用.
科学领域:
- 老年学是指老年学的学科.
- 预防心血管疾病 预防心血管疾病
- 营养科学 营养科学
背景情况:
- 使用非药物干预措施预防老年人心血管疾病 (CVD) 需要进一步调查.
- 在DO-HEALTH试验中,评估了70岁以上欧洲成年人的干预措施.
研究的目的:
- 评估维生素D3,omega-3脂肪酸和简单的家庭力量炼计划 (SHEP) 对心血管疾病生物标志物和事件的影响.
- 确定这些干预措施在预防事件高血压和主要心血管不良事件 (MACE) 的有效性.
主要方法:
- 一个多中心的,随机的,安慰剂控制的,2x2x2因子试验 (DO-HEALTH) 涉及2157名参与者.
- 干预包括维生素D3 (2000 IU/天),欧米茄-3脂肪酸 (1 g/天) 和SHEP (3x/周) 在3年内.
- 终点包括脂质生物标志物的变化,发生的高血压和MACE (冠状动脉事件,心力衰竭,中风).
主要成果:
- 补充omega-3改变了脂质生物标志物,增加了HDL胆固醇和甘油三,同时也提高了总胆固醇,LDL胆固醇和非HDL胆固醇.
- 与对照组相比,欧米茄-3,维生素D3和SHEP都没有显著降低MACE或事件高血压的风险.
- 研究群体一般是健康的,活跃的,在基线时大部分维生素D充足.
结论:
- 在健康,活跃和维生素D补充的老年人中,欧米茄-3,维生素D3和SHEP在预防MACE方面没有显示好处.
- 补充omega-3对脂质生物标志物产生混合作用,但没有提供心血管保护.
- 根据研究结果,这些干预措施不建议在这个人口群体中预防MACE.
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