患有慢性治疗性血交换患者的贫血
Nichole LePage1, Esther Soundar1
1Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
概括
慢性治疗性血交换 (TPE) 可以导致成人患者的贫血. 这项研究发现贫血迅速发展,即使在没有先前存在的贫血患者中也是如此,这凸显了监测的必要性.
科学领域:
- 血液学 血液学 血液学
- 神经学 神经学
- 身体以外的治疗方法
背景情况:
- 治疗性血交换 (TPE) 是一种成熟的体外治疗方法,具有普遍有利的安全性.
- 贫血不是慢性TPE常见的不良影响.
- 了解潜在的不良影响,如贫血,对于长期的患者管理至关重要.
研究的目的:
- 为了调查慢性,每周一次的TPE接受的成年患者贫血的发生率.
- 为了确定长期TPE治疗期间贫血发病的发病时间.
- 评估TPE对患有或没有先前存在的贫血患者的血红蛋白水平的影响.
主要方法:
- 从2017年7月到2020年3月,至少每周一次接受TPE的成人门诊患者的回顾性审查.
- 卡普兰-梅尔分析来计算贫血发展和血红蛋白减少的时间.
- 纳入标准:有14名患有神经系统疾病 (如肌痛性肌痛症) 的患者接受慢性TPE治疗.
主要成果:
- 在基线时,29%的患者患有贫血 (血红蛋白中位数为9.4 g/dL).
- 所有患者在开始慢性TPE后6周内经历了1g/dL的血红蛋白降低.
- 非贫血患者在10周内患有贫血;中度贫血患者在6周内发展为严重贫血.
结论:
- 贫血是慢性治疗性血交换的重要后果.
- 早期和定期监测血红蛋白水平对于诊断TPE诱导的贫血至关重要.
- 积极的实验室评估对于长期治疗TPE患者的管理至关重要.
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