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PET/计算机断层扫描瘤学的转变:免疫疗法评估
Alireza Ghodsi1, Rodney J Hicks2, Amir Iravani1
1Department of Radiology, University of Washington, 1144 Eastlake Avenue East, Seattle, WA 98109, USA.
PET clinics
|January 10, 2024
概括
免疫疗法提供了新的癌症治疗选择,但需要先进的成像. 本综述探讨了18F-FDG PET/CT和新型免疫-PET追踪剂,用于监测癌症免疫治疗中的治疗反应和不良事件.
科学领域:
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
- 分子成像学分子成像学
背景情况:
- 癌症免疫疗法彻底改变了恶性瘤的治疗方法,显示出显著的抗瘤反应.
- 免疫治疗中的新反应和进展模式对传统的评估标准提出了挑战,例如RECIST 1.1.
- 混合分子成像提供了一种全面的方法,超出了CT和MRI的形态细节,探测病理生理机制.
研究的目的:
- 审查2-deoxy-2-[18F]-D-葡萄糖正子发射断层扫描/计算机断层扫描 (18F-FDG PET/CT) 在癌症免疫治疗中的当前应用.
- 突出18F-FDG PET/CT在预后,反应监测和识别免疫相关不良事件中的作用.
- 调查新型免疫PET标记物的潜力,以补充18F-FDG PET/CT用于成像免疫疗法途径.
主要方法:
- 关于18F-FDG PET/CT在癌症免疫治疗中的当前文献的综述.
- 讨论混合分子成像在评估治疗反应方面的能力.
- 探索针对性成像的新兴免疫PET标记物的探索.
主要成果:
- 18F-FDG PET/CT对于预后,监测治疗反应和检测免疫治疗中的免疫相关不良事件非常有价值.
- 混合成像模式为治疗期间的病理生理变化提供了洞察力.
- 新型免疫-PET标记剂在可视化特定免疫疗法标方面表现有前途.
结论:
- 18F-FDG PET/CT在接受免疫治疗的癌症患者的管理中起着至关重要的作用.
- 免疫-PET标记剂提供了补充信息,可能提高免疫疗法疗效的评估.
- 先进的成像技术对于优化癌症免疫治疗策略至关重要.
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