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Updated: Jul 6, 2025

Assessing Cellular Target Engagement by SHP2 PTPN11 Phosphatase Inhibitors
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在肝细胞癌中,TRIM22通过向PHLPP2诱导细胞衰老

Donghee Kang1,2,3, Hyun Jung Hwang1,3, Yurim Baek1,2,3

  • 1Research Center for Controlling Intercellular Communication, College of Medicine, Inha University, Incheon, 22212, Korea.

Cell death & disease
|January 10, 2024
PubMed
概括

在肝细胞癌 (HCC) 中,E3泛基因酶TRIM22通过降解PHLPP2诱导细胞衰老. 这种TRIM22-PHLPP2相互作用激活了AKT-p53-p21信号,为HCC治疗提供了潜在的治疗标.

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