定义人类"表面器官"中的微生物组的生物地理地图和潜在的细菌转移
Jun-Jun She1,2,3,4, Wei-Xin Liu5, Xiao-Ming Ding6,7
1Department of General Surgery, First Affiliated Hospital of Xi'an Jiao Tong University, Xi'an, China. junjunshe1975@sina.com.
Nature communications
|January 10, 2024
概括
这项研究在已故个体的多个器官中绘制了人类微生物组的地图. 它揭示了器官之间的显著变异和共享的微生物物种,为微生物相互作用和功能提供了洞察力.
科学领域:
- 微生物学 微生物学
- 人类微生物组研究研究
- 系统生物学 系统生物学
背景情况:
- 个体器官的微生物组具有良好的特征.
- 对人类多器官微生物组的全面分析仍然有限.
- 了解器官间的微生物动态对于人类健康至关重要.
研究的目的:
- 分析已故人类的个体内,器官间和器官内微生物组.
- 描述微生物多样性,组成和多个器官之间的相互作用.
- 为了确定特定地点的微生物特征和功能特征.
主要方法:
- 从7个表面器官 (口腔,食道,胃,小肠,尾,大肠,皮肤) 的53个部位收集了1608个样本,来自33名受试者.
- 进行了16S全长测序,用于微生物组概况.
- 分析了微生物多样性,不同地点和样本类型 (粘膜-光层) 之间的共存和异质性.
主要成果:
- 在不同器官中观察到显著的微生物多样性变化.
- 识别了在多个个体内器官共存的核心微生物物种.
- 在胃,小肠和大肠中的配对粘膜-光膜样本之间揭示了微生物异质性.
- 沿消化道建立了器官间微生物关系的景观.
- 描述了特定位置的微生物特征,功能特征和相互作用.
结论:
- 在器官间和器官内部产生了细菌组成,多样性,相互作用和功能特征的全面目录.
- 突出了人类微生物组在不同器官中的复杂性和相互联系.
- 为了解微生物转移及其影响提供了基础数据.
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